系统性红斑狼疮
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澳门第一赌城在线娱乐对系统性红斑狼疮的看法
Systemic 红斑狼疮 erythematosus (SLE) is a chronic immune-driven disease in which the body’s immune system attacks healthy tissue in any part of the body.1 It’s experienced differently by each person and can cause a wide range of debilitating symptoms, 包括皮疹, 关节疼痛, 肿胀和发烧.2 There have been very few new medicines for SLE, and the significant physical, emotional and
该病患者的社会经济负担仍然很高.3,4
Our researchers are working to unlock the science of the immune system to address the significant unmet needs in 红斑狼疮. By highlighting the experiences from people with SLE and investigating the underlying drivers of this complex disease, we aim to bring scientific advancements to the 红斑狼疮 community and challenge the boundaries they’ve had to accept for too long.
病人的肖像
狼疮对每个人的影响是不同的，而且可能是不可预测的. Hear from people with systemic 红斑狼疮 erythematosus (SLE) on how the disease has impacted their lives since diagnosis, 以及他们对该领域科学进步的希望.
英格丽。
US
狼疮患者的生活
I was diagnosed with 红斑狼疮 when I was 23 and have been a 红斑狼疮 Warrior for 17 years. 在我人生的不同阶段, 我经历了各种症状, 包括皮疹, 关节疼痛和极度疲劳, 除了与病情相关的情感之旅. 有时这些会让人虚弱，就像坐过山车一样. 有高潮，也有低谷. But I’m more hopeful today than ever that scientific progress is being made to help improve the lives of people like me who are living with 红斑狼疮.
朱利
德国
狼疮患者的生活
2018年，19岁的我被诊断出患有狼疮. 在过去的几年里, I’ve experienced severe pain in my joints and connective tissues and suffered hair loss and excessive sweating. There are days when I can hardly move; there are days when I’m sad or angry, 但我已经接受了我的病. Still, it’s important to continue raising awareness of 红斑狼疮 and the different treatment options. I want others living with 红斑狼疮 to remain hopeful for the future and remember that 红斑狼疮 lives with you, 你没有狼疮.
解决狼疮社区未满足的需求
SLE在非洲、亚洲或西班牙裔人群中更为常见.6 据估计，90%的SLE患者是女性.1
New treatments are needed to address the significant unmet medical needs faced by those living with 红斑狼疮 and their healthcare professionals. 病人对疾病的控制仍然不足, 与健康有关的生活质量差的结果和相关的健康状况. 许多SLE患者依赖于长期使用口服皮质类固醇, which can be helpful in addressing increases in disease activity but can also increase the risk of organ damage and other significant side effects.3,7,8,9
Managing organ damage and more serious disease characteristics often requires more costly care.10 跨越多个国家, we found that earlier diagnosis and treatment are crucial to lowering the financial burden of SLE, 并且可以帮助降低疾病进展的风险和发作频率, 防止器官损伤，提高生活质量.11-15
We are continuing to follow the science to further unlock our understanding of complex immune-driven diseases like SLE. 如果澳门第一赌城在线娱乐能够认识到并解决疾病的潜在驱动因素, 澳门第一赌城在线娱乐可以解决仍未满足需求的关键领域.
揭开SLE的奥秘
For people living with SLE, the immune system inappropriately attacks healthy tissue in the body.1 SLE疾病活动包括B, T和树突状细胞, 以及炎性细胞因子如1型干扰素(IFN-1), IL-6和b细胞活化因子. 细胞因子是起免疫信号传导作用的分子, regulating processes along immune pathways that coordinate the overall immune response. 这会导致过度激活的免疫反应, which along with the creation of autoantibodies (antibodies formed in response to the body’s own tissues), 会导致伤害, 炎症和长期器官损伤. 高达60-80%的成人SLE患者可能有IFN-1基因升高, 哪些与疾病严重程度增加有关.16-21
通过了解关键炎症细胞因子在级联反应中的作用, 澳门第一赌城在线娱乐可以开始进一步揭开这种具有挑战性的疾病的复杂本质.
参考文献
1. 美国狼疮基金会. 什么是狼疮? 可在:http://www.红斑狼疮.org/resources/what-is-红斑狼疮. 2023年5月.
2. 美国风湿病学会. Guidelines for referral and management of systemic 红斑狼疮 erythematosus in adults. 关节炎 & 风湿病学. 1999;42:1785-1796.
3. Mahieu MA，等. 系统性红斑狼疮临床试验综述. 红斑狼疮. 2016; 25 (10): 1122-1140
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6. 李丽娟，张建军，张建军，等. Worldwide incidence and prevalence of systemic 红斑狼疮 erythematosus: a systematic review of epidemiological studies. 风湿病学. 2017;56(11), pp. 1945-1961.
7. 哈里斯，J，莫兰，E. 社论:关注系统性红斑狼疮. 前面Immunol. 2016;7:400. doi: 10.3389 / fimmu.2016.00400.
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11. 刘建军，张建军，张建军，等. 系统性红斑狼疮的性别差异:流行病学, 临床考虑, 及发病机制. 梅奥临床项目. 2020;95(2):384–394.
12. Hammond ER, Murimi IB, Lin DH，等. Health Care Utilization and Costs of 系统性红斑狼疮 in the United States: A Systematic Review [poster]. 发表于:欧洲抗风湿病联盟, 欧拉描述, European Congress of 风湿病学 2017; 14-17 June 2017. 摘要ID: SAT0227.
13. 李建平，李建平，李建平，等. Health Care Utililization and Costs of 系统性红斑狼疮 by Disease Severity in the United States. J Rheumatol. 2020;191187. doi: http://doi.org/10.3899 / jrheum.
14. 李建军，李建军，李建军，等. Health care resource use (hru) and medical cost analyses as a function of systemic 红斑狼疮 erythematosus (sle) disease severity: analysis of claims data of a german sickness fund. 狼疮科学医学. 2018;5. doi: 10.1136.
15. Yeo AL, Koelmeyer R, Kandane-Rathnayake R，等. 红斑狼疮 Low Disease Activity State is Associated with Reduced Direct Healthcare Costs in Patients with 系统性红斑狼疮 [published online ahead of print, 2019年7月8日]. 关节炎护理中心(霍博肯). 2020年9月,72 (9):1289 - 1295.
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17. 刘国强，刘国强，刘国强. Type I interferon blockade in systemic 红斑狼疮 erythematosus: where do we stand? Rheumatol. 2014;53(8):1369-1376.
18. Hoffman RW, Merrill JT, Alarcón-Riquelme MM，等. 基因表达及药效学变化,760 systemic 红斑狼疮 erythematosus patients from two phase III trials of BAFF blockade with tabalumab. 关节炎Rheumatol. 2017;69(3):643-654.
19. Becker AM, Dao KH, Han BK，等. SLE外周血B细胞, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature. 《澳门第一赌城在线娱乐》. 2013;8(6):e67003.
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[21]李建军，李建军，李建军，等. The baseline interferon signature predicts disease severity over the subsequent 5 years in systemic 红斑狼疮 erythematosus. 关节炎治疗. 2021;23:29
Veeva ID: Z4-54681
编制日期:2023年5月